Lab — Protein Design Part I

Protein features diagram

Tip

This week’s lab is entirely in‑silico — no in‑person wet‑lab.

Concepts You’ll Learn

  • Protein prediction tools
  • Sequence recovery models
  • Generative models
  • Designing toward desired physicochemical properties

Lab Protocol

The protein design lab will be entirely in‑silico; you’ll run a variety of models to test different protein designs.

Picture source: Hou, Feenstra et al., 2022 — “Ten quick tips for sequence‑based prediction of protein properties using machine learning,” PLOS Comput Biol 18(12): e1010669.