Lab — Gibson Assembly

Tip

This week’s lab pairs directly with the Homework. Use the protocol and primer‑design notes below; document your process and results.

Objective

Practice DNA assembly by preparing linear fragments (via PCR and/or restriction digest) and assembling them with Gibson Assembly, followed by transformation into E. coli.

Concepts You’ll Learn

  • Primer design fundamentals
  • PCR setup and thermocycling
  • Restriction digests & buffer selection
  • Gibson Assembly principles & workflow
  • Transformation and selection

Protocol & Prep

Gibson assembly figure