Lab — Imaging & Measurement

Tip

This week’s practical focuses on LC‑MS workflows for eGFP characterization (intact mass and peptide mapping). On‑site work takes place at Waters Immerse Cambridge; remote students will use the shared dataset.

Objective

Connect measurement to design by acquiring and interpreting LC‑MS data.

Concepts You’ll Learn

  • Sample prep for intact mass vs peptide mapping
  • Fundamentals of LC‑MS instrumentation & readouts
  • Native vs denatured protein measurements
  • Basic analysis and documentation

Mass spectrometry schematic