Week 13: Bio Design, Living Materials

Context
This week focuses on engineered living materials (ELMs) and bio-based design—materials that incorporate living cells (or biologically grown matter) to achieve properties like sensing, self-healing, and biodegradability.
Goals
- Survey the landscape of living materials (bacterial cellulose, engineered biofilms, mycelium composites, algae-based materials).
- Frame a use-case and a design concept (function, organism, matrix, lifecycle).
- Consider safety, containment, and environmental impact at a concept level.
Part A — Rapid landscape scan (mini-review)
Create a 6–10 bullet mini-review that covers:
- At least three classes of living/bio-grown materials (e.g., engineered bacterial biofilms, mycelium composites, algal biopolymers, bacterial cellulose pellicles).
- One strength and one limitation for each class (stability, rate of growth, hydration/processing, biosafety).
- 3–5 external references (papers, reviews, or credible overviews).
Tip: Look for high-level reviews on ELMs, plus concrete examples from design/architecture.
Part B — Concept sketch (your living material)
Write a one-pager describing a living material concept:
- Purpose / scenario — What job should the material do (e.g., humidity-responsive façade tile, self-healing fill, low-energy lighting, degradable packaging)?
- Biology — Which organism(s) and why (traits, growth conditions, containment considerations)?
- Matrix / form — What scaffold or composite? Film, foam, “brick,” hydrogel, textile, or printed shell?
- Signals & response — What should it sense or do? (e.g., color change, conductivity change, mechanical strength, VOC capture)
- Lifecycle — Sourcing, use, end-of-life (compost, deactivation, reuse).
- Risks & mitigations — Non-pathogenic strains; kill-switch ideas; storage/transport constraints; disposal.
Add one figure (hand sketch or diagram) and a short materials/parts list (conceptual—no lab protocol required).
Part C — “Feasibility notes”
Add a short section (6–8 bullets) on what you’d need to test next:
- Minimum growth time / production rate
- Moisture and temperature envelope
- Mechanical or optical property you’d measure first
- Containment plan (transport, dormancy, disposal)
- What a simple benchtop mock (no live cells) could tell you
Deliverables
- Mini-review (Part A) with 3–5 references
- Concept one-pager + diagram (Part B)
- Feasibility notes (Part C)
- 2–3 illustrative images (own sketches/mockups are fine)
References / jumping-off points
- Engineered living biomaterials (Nature Reviews Materials) — broad review of ELMs that incorporate microorganisms into polymer matrices. https://www.nature.com/articles/s41578-021-00350-8.pdf
- Living materials from engineered microbes (Nature Materials) — programmable functionality and design considerations. https://www.nature.com/articles/s41563-020-00857-5.pdf
- Taxonomies & trends in ELMs (Trends in Biotechnology). https://www.cell.com/trends/biotechnology/fulltext/S0167-7799%2820%2930273-0
- Programmable bacterial biofilms as ELMs (Accounts of Materials Research). https://pubs.acs.org/doi/pdf/10.1021/accountsmr.3c00271
- Mycelium bio-composites in design/architecture (Journal of Cleaner Production review). https://www.sciencedirect.com/science/article/pii/S0959652619339071
- Design stories on living materials (TU Delft). https://www.tudelft.nl/en/stories/articles/alive-and-kicking-designing-with-living-materials/