<?xml version="1.0" encoding="utf-8" standalone="yes"?><rss version="2.0" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Week 5 Homework: Protein Design Part II :: 2026a-ade-larsen</title><link>https://pages.htgaa.org/2026a/ade-larsen/homework/week-05-hw-protein-design-part-ii/index.html</link><description>Part 1: Generate Binders with PepMLM The target for this study is the human SOD1 protein (UniProt P00441), specifically focusing on the A4V mutation, which is a common cause of Amyotrophic Lateral Sclerosis (ALS).
Mutant SOD1 Sequence (A4V):
ATKVVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
Using PepMLM-650M, four peptides of 12 amino acids were generated and compared against the known SOD1-binding peptide FLYRWLPSRRGG.</description><generator>Hugo</generator><language>en</language><atom:link href="https://pages.htgaa.org/2026a/ade-larsen/homework/week-05-hw-protein-design-part-ii/index.xml" rel="self" type="application/rss+xml"/></channel></rss>