• 1. First, describe a biological engineering application or tool you want to develop and why.
  • 2. Next, describe one or more governance/policy goals related to ensuring that this application or tool contributes to an “ethical” future, like ensuring non-malfeasance (preventing harm). Break big goals down into two or more specific sub-goals.
  • 3. Next, describe at least three different potential governance “actions” by considering the four aspects below (Purpose, Design, Assumptions, Risks of Failure & “Success”)
  • 4. Next, score (from 1-3 with, 1 as the best, or n/a) each of your governance actions against your rubric of policy goals.
  • 5. Last, drawing upon this scoring, describe which governance option, or combination of options, you would prioritize, and why. Outline any trade-offs you considered as well as assumptions and uncertainties.
  • Homework Questions from Professor Jacobson:
    • 1. Nature’s machinery for copying DNA is called polymerase. What is the error rate of polymerase? How does this compare to the length of the human genome. How does biology deal with that discrepancy?
    • 2. How many different ways are there to code (DNA nucleotide code) for an average human protein? In practice what are some of the reasons that all of these different codes don’t work to code for the protein of interest?
  • Homework Questions from Dr. LeProust:
    • 1. What’s the most commonly used method for oligo synthesis currently?
    • 2. Why is it difficult to make oligos longer than 200nt via direct synthesis?
    • 3. Why can’t you make a 2000bp gene via direct oligo synthesis?
  • Homework Question from George Church:
    • 1. What are the 10 essential amino acids in all animals and how does this affect your view of the “Lysine Contingency”?
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