https://pages.htgaa.org/2026a/alya-alobaidi/homework/week-05-hw-protein-design-part-ii/index.htmlImage source: Genetic Lifehacks. https://www.geneticlifehacks.com/sod1-gene-polymorphisms/ Part 1: SOD1 Binder Peptide Design “MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ” This is the SOD1 original sequence The mutation A4V means: Alanine (A) at position 4 → Valine (V) But UniProt includes the starting M, so the alanine that changes is the 5th residue in the sequence. 1 M 2 A 3 T 4 K 5 A ← this is the one that changes 6 V We change from this MATKAV to this MATKVVHugoen