https://pages.htgaa.org/2026a/ana-gomez/homework/week-05-hw-protein-design-part-ii/index.htmlWeek 5: Protein Design Part II Part A: SOD1 Binder Peptide Design (From Pranam): What I know about SOD1 and its mutation: (Berdyński et al., 2022) Mutations in SOD1 cause familial Amyotrophic Lateral Sclerosis (ALS) ALS is a heterogeneous, severe neurodegenerative disorder, the hallmark of which is an adult-onset loss of upper and lower motor neurons. It leads to a progressive paresis and atrophy of skeletal muscles, resulting in quadriplegia and fatal respiratory failure. The mutation subtly destabilizes the N-terminus, perturbs folding energetics, and promotes toxic aggregation. Challenge of this week: Design short peptides that bind mutant SOD1 & then decide which ones are worth advancing toward therapy.Hugoen