https://pages.htgaa.org/2026a/anastasia-ntavou/homework/week-12/index.htmlGlobal Listener — Anastasia Ntavou | Athens, Greece Project: Mycelium Surfboard (Ganoderma lucidum engineering) Reflection: Genome-Scale Engineering & the Mycelium Surfboard This week’s lectures on synthetic genomes — from JCVI-syn3.0 (473 genes) to Sc2.0 — provided important context for the mycelium surfboard project. Minimal genomes: JCVI-syn3.0 has ~30% genes with unknown function. For G. lucidum (~49 Mb, ~16,000 genes), the complexity is vastly greater — reinforcing why targeted CRISPR knock-in (2 genes) is the right strategy rather than whole-genome redesign.Hugoen