Week 5 HW: Protein Design Part II

Part A. SOD1 Binder Peptide Design

Part 1: Generate Binders with PepMLM The goal of this exercise is to take a Human SOD1 sequence from UniProt (P00441)

MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ

A4V mutation