Homework
Weekly homework submissions:
Week 1 HW: Principles and Practices
Programming living neural systems: design of iPSC-derived neuronal organoids for personalized neurodegenerative disease research. Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS) remain poorly understood and pose a significant challenge to modern medicine due to their high public health burden and negative impact on patients’ quality of life. There have been significant advances in experimental neuroscience, but current experimental models fail to accurately reproduce the specific neural development or progressive nature of these disorders.
Homework Questions from Professor Jacobson Nature’s machinery for copying DNA is called polymerase. What is the error rate of polymerase? How does this compare to the length of the human genome. How does biology deal with that discrepancy? Polymerase is an enzyme whose function is to produce a chain of nucleic acids by copying another chain that serves as a template. It is basically the enzyme that copies DNA during replication. The error made by DNA polymerase consists of incorporating an incorrect nucleotide, that is, placing a base that is not complementary to that of the template (for example, placing A where C should go).