Homework

Week 1 HW: Principles and Practices
My Homework A Logic-Gated Bispecific Nanobody Approach to Overcome Immune Resistance in Multiple Myeloma First, describe a biological engineering application or tool you want to develop and why. Multiple myeloma is a cancer of plasma cells that develop and persist within the bone marrow, where disease progression is strongly shaped by interactions with the immune microenvironment. Therapies which are targeting CD38, a protein highly expressed on myeloma cells, have significantly improved patient outcomes. However, many patients either fail to respond or relapse after initial treatment. This resistance is increasingly understood to arise not only from changes within tumor cells, but also from therapy-induced immune dysfunction, including impaired natural killer cell activity, T-cell exhaustion, expansion of suppressive myeloid cells, and altered CD38 expression on both malignant and healthy immune cells.