Homework

Weekly homework submissions:

• Week 1 HW: Principles and Practices

  Question 1: Biological Engineering Application / Tool A Multiscale Computational Platform for Predictive Tissue Morphogenesis. I want to develop a computational–experimental platform that predicts tissue-level morphogenesis from gene regulatory, cellular, and mechanical inputs, with a particular focus on developmental defects and regenerative biology. The core of the tool would integrate: Single-cell transcriptomics and spatial transcriptomics (to capture gene expression states). Agent-based models (e.g cellular Potts or vertex models) to represent cell–cell interactions, division, and differentiation. Continuum mechanics (ECM stiffness gradients, stress fields) to model tissue-scale forces. The platform would allow researchers to simulate counterfactual interventions—for example: