https://pages.htgaa.org/2026a/aryan-boruah/homework/index.htmlWeekly homework submissions: Week 1 HW: Principles and PracticesHugoenhttps://pages.htgaa.org/2026a/aryan-boruah/homework/week-01-hw-principles-and-practices/index.htmlMon, 01 Jan 0001 00:00:00 +0000https://pages.htgaa.org/2026a/aryan-boruah/homework/week-01-hw-principles-and-practices/index.htmlQuestion 1: Biological Engineering Application / Tool A Multiscale Computational Platform for Predictive Tissue Morphogenesis. I want to develop a computational–experimental platform that predicts tissue-level morphogenesis from gene regulatory, cellular, and mechanical inputs, with a particular focus on developmental defects and regenerative biology. The core of the tool would integrate: Single-cell transcriptomics and spatial transcriptomics (to capture gene expression states). Agent-based models (e.g cellular Potts or vertex models) to represent cell–cell interactions, division, and differentiation. Continuum mechanics (ECM stiffness gradients, stress fields) to model tissue-scale forces. The platform would allow researchers to simulate counterfactual interventions—for example: