<?xml version="1.0" encoding="utf-8" standalone="yes"?><rss version="2.0" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Week 5: Protein Design 2 :: 2026a-asaf-balaga</title><link>https://pages.htgaa.org/2026a/asaf-balaga/homework/week-05-protein-design-2/-_index/index.html</link><description>This week, we need to find a favorable peptide to bind into the mutated (A4V) version of a SOD1 enzyme.
Part 1: Generate Binders with PepMLM
This is the original sequence of SOD1 as it appears here.
sp|P00441|SODC_HUMAN Superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD1 PE=1 SV=2 MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
Changing the 4th residue (In much of the SOD1/ALS literature, that first methionine (M) is considered removed in the mature protein, so residue numbers shift by minus 1.)</description><generator>Hugo</generator><language>en</language><atom:link href="https://pages.htgaa.org/2026a/asaf-balaga/homework/week-05-protein-design-2/-_index/index.xml" rel="self" type="application/rss+xml"/></channel></rss>