HTGAA'26 — Beyza Batır — Proposal Ideas
Idea.2: Paleo-Proteins
Neurological protection through Ice Age resilience. Ancient chaperone proteins redesigned by LLMs to prevent amyloid aggregation in Alzheimer's disease.
01 — Ancient source
Ice age organism
Source chaperone sequence
Select an organism to extract chaperone protein sequence...
02 — LLM protein design
Synthetic chaperone
ProteinMPNN + ESMFold output
Awaiting source sequence...
03 — Opentrons screening
96-well aggregation assay
Low inhibitionHigh inhibition
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Source organism
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Variants generated
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Top hit well
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Aggregation reduction
ThT fluorescence kinetics
No chaperone (control)
Paleo-protein treated
Analysis
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