https://pages.htgaa.org/2026a/casian-veselin/homework/week-05-hw-protein-design-ii/index.htmlWeek 5 Protein Design part II; Superoxide dismutase 1 (SOD1) – cytosolic antioxidant enzyme that converts superoxide radicals (O2-) into H2O2 and O2. In its native state, it forms a stable homodimer and binds Co and Zn. Mutations in SOD1 cause familial Amyotrophic Sclerosis (ALS). A4V leads to most aggressive forms of disease, as it destabilizes the N-terminus, perturbs folding energetics and promotes toxic aggregation.Hugoen