<?xml version="1.0" encoding="utf-8" standalone="yes"?><rss version="2.0" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Week 5 HW: Protein Design part II :: 2026a-devorah-wertheimer</title><link>https://pages.htgaa.org/2026a/devorah-wertheimer/homework/week-05-hw-protein-design-part-ii/index.html</link><description>Part A: SOD1 Binder Peptide Design sequences, scores, structure, and properties for all peptides
PepMLM binder generation Perplexity scores for known and generated peptides: Alphafold binder evaluation ipTM Values and Comparison to Known Binder The ipTM values across all peptides are low, ranging from 0.27 to 0.43, and none exceed 0.5 — the general threshold for confident protein-peptide interaction prediction. Notably, two PepMLM-generated peptides (Sequence_0 at 0.40 and Sequence_1 at 0.43) actually exceed the known binder (Sequence_4 at 0.32), suggesting the model produced candidates with comparable or slightly better predicted interface confidence. However, all predictions share the same binding</description><generator>Hugo</generator><language>en</language><atom:link href="https://pages.htgaa.org/2026a/devorah-wertheimer/homework/week-05-hw-protein-design-part-ii/index.xml" rel="self" type="application/rss+xml"/></channel></rss>