Projects

Individual Final Project
Project Description Development of a platform for culturing intestinal spheroids (from cell lines, such as Caco-2) for studying drug absorption and/or diagnosing IBD. Additionally, the project includes software capable of directly analyzing data from the cultures, such as protein expression (ABC transporters), as well as proteomics, metabolomics, and genomics information.
Group Final Project
Proposal: Rational Enhancement of MS2 Lysis Protein Toxicity Objective This proposal addresses the subproblem of increasing the toxicity of the L lysis protein from Bacteriophage MS2. Instead of random mutagenesis, toxicity will be approached as a multi-factor optimization problem involving structural stability, membrane insertion, oligomerization efficiency, and expression kinetics in Escherichia coli. The objective is to design L variants that enhance membrane disruption while maintaining proper folding and stability.