Bacteriophage Engineering

GROUP MEMBERS

Diogo Custodio https://pages.htgaa.org/2026a-diogo-custodio/

Flo Razoux https://pages.htgaa.org/2026a-flo-razoux/

Katharine Kolin https://pages.htgaa.org/2026a/katharine-kolin/

Marisa Satsia https://pages.htgaa.org/2026a-marisa-satsia/

Main goals (tbc)

• Increased stability (easiest)
• Higher titers (medium)
• Higher toxicity of lysis protein (hard)

Proposal (to be updated on March 8th)

• Which tools/approaches from recitation you propose using (e.g., “Use Protein Language Models to do in silico mutagenesis, then AlphaFold-Multimer to check complexes.”).
• Why do you think those tools might help solve your chosen sub-problem?
• Name one or two potential pitfalls (e.g., “We lack enough training data on phage–bacteria interactions.”).
• Include a schematic of your pipeline.

Individual and group plan for engineering a bacteriophage (to be updated on March 8th)