Week 5 HW: Protein design part 2 :: 2026a-ganapathi-naayagamhttps://pages.htgaa.org/2026a/ganapathi-naayagam/homework/week-05-hw-protein-design-part-ii/index.htmlDesign short peptides that bind mutant SOD1. Then decide which ones are worth advancing toward therapy. Uniprot SOD1 protein sequence: sp|P00441|SODC_HUMAN Superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD1 PE=1 SV=2 MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ Apply A4V mutation: (ignoring Methionine) The Bolded V used to be A MATKVVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ Pepmlm Generated peptides and their perplexity score:Hugoen