Homework

WK-01 Governance diagram
WEEK 01 / PRINCIPLES + PRACTICES
Principles & Practices

Growing Serratia marcescens and Bacillus sp. pigments for bio-art. Mechanotransduction experiments. Governance framework for engineered organisms in gallery settings.

WK-02 Benchling plasmid
WEEK 02 / DNA READ, WRITE & EDIT
DNA Read, Write & Edit

Codon-optimising VioC from C. violaceum. Circadian antimicrobial system. Magainin peptide under RpaA promoter. Twist synthesis order prep.

WK-03 Opentrons
WEEK 03 / HW + LAB / OPENTRONS
Week 3 HW/Lab: Opentrons

Draft final project directions. Weighing Twist costs, remote lab availability, and UK-based ordering constraints to identify the most viable pathway.

WK-04 GABARAPL2 surface
WEEK 04 / PROTEIN DESIGN PT.I
Protein Design I

GABARAPL2 analysis in PyMol (PDB 7LK3). ESM2 mutational scan, t-SNE latent space, ESMFold, ProteinMPNN inverse folding. Bacteriophage engineering brainstorm.

WK-05 AlphaFold3 SOD1 binder structures
WEEK 05 / PROTEIN DESIGN PT.II
Protein Design II

SOD1-A4V binder peptide design. PepMLM generation, AlphaFold3 evaluation, PeptiVerse property scoring, moPPIt optimisation. L-protein mutant plan for MS2 phage lysis.

WK-06 Genetic circuits DNA assembly
WEEK 06 / GENETIC CIRCUITS PT.I
Genetic Circuits I

DNA assembly and PCR components. Phusion High-Fidelity Master Mix, primer annealing, amilCP chromophore mutagenesis, and genetic circuit design fundamentals.

WK-07 Weiss Lab IANN run
WEEK 07 / GENETIC CIRCUITS PT.II
Genetic Circuits II

IANNs vs Boolean circuits. KaiClock + Durin parallel AND gate run at Weiss Lab. Fungal materials, mycelial pigment lightfastness. Twist DNA order review.

WK-09 Silk fibre earth vs space
WEEK 09 / CELL FREE SYSTEMS
Cell Free Systems

Cell-free protein synthesis advantages. Lyme disease biosensor synthetic cell design. Freeze-dried silk protein self-repair in soft robotics. BioBits space proposal for MaSp1 microgravity assembly.

WK-10 Mass spectrometry charge state analysis
WEEK 10 / IMAGING & MEASUREMENT
Imaging & Measurement

eGFP molecular weight from amino acid sequence. Adjacent charge state mass calculation. Tryptic digest peptide mapping. Native vs denatured mass spectrometry analysis.

WK-11 1536 pixel collaborative canvas
WEEK 11 / BIOPRODUCTION + CLOUD LABS
Bioproduction & Cloud Labs

1,536 pixel collaborative canvas. Cell-free reagent analysis. mTurquoise2 nicotinamide hypothesis for chromophore maturation. Global cell-free master mix design.