Projects

Final projects:

• Individual Final Project

  SECTION 1: ABSTRACT Provide a concise, self-contained summary of your project (minimum 150 words). The abstract should allow a reader to understand the purpose, approach, and expected outcomes of the work without referring to other sections.

  1. Your abstract should briefly address the following elements: a. Significance: What problem or question does the project address, and why is it important?
• Group Final Project

  PROJECT OBJECTIVE Engineer the L protein of the MS2 phage to increase structural stability. Disrupt or reduce its interaction with the bacterial chaperone DnaJ. Preserve the C-terminal lysis domain to maintain lytic function. Avoid mutations that interfere with structurally or evolutionarily coupled residues. Phase 1: Mapping the DnaJ Interaction Interface Since the exact binding interface between the L protein and DnaJ is unknown, the first step is to identify it computationally rather than introducing arbitrary mutations.