https://pages.htgaa.org/2026a/isobel-jo-leonard/homework/week-05-hw-protein-design-part-ii/index.htmlImportant Resources Lecture Recording 1 Lecture Recording 2 Recitation Recording Recitation Slides PART 1: Generate Binders with PepMLM Begin by retrieving the human SOD1 sequence from UniProt (P00441) and introducing the A4V mutation. SOD1 Sequence from Uniprot is: MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ Mutations in SOD1 causes familial Amyotrophic Lateral Sclerosis (ALS). Among these mutations, one that causes a very aggressive form of the disease is the A4V mutation (where residue 4 is changed from Alanine → Valine). Introducing A4V mutation makes the sequence:Hugoen