Homework
Weekly homework submissions:
Week 1 HW: Principles and Practices
Homework # 1 I would like to train models which can generate genomes and reason or provide information about the function of the genome. Tools like this have already been developed, including Evo 2, which can identify functionally important mutations (for example, mutations in BRCA1 in humans). It has also been used to generate an entire bacteriophage genome.
Professor Jacobson 1. Nature’s machinery for copying DNA is called polymerase. What is the error rate of polymerase? How does this compare to the length of the human genome. How does biology deal with that discrepancy? The error rate of polymerase is 1 error for every $10^6$ bases. In the human genome there are approximately 3.2 billion base pairs [1]. This means we expect on average 3,200 errors in every cell division. This is extraordinarily high at first glance. However, nature deals with this via an error correction system called the MutS repair system, which helps to repair these errors.