<?xml version="1.0" encoding="utf-8" standalone="yes"?><rss version="2.0" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>week-09-hw-cell-free-systems :: 2026a-kaleab-berhanu-weldesenbet</title><link>https://pages.htgaa.org/2026a/kaleab-berhanu-weldesenbet/homework/week-09-hw-cell-free-systems/index.html</link><description>Homework question from Kate Adamala. Design an example of a useful synthetic minimal cell as follows:
Pick a function and describe it. a. What would your synthetic cell do? What is the input, and what is the output?
The cell-free genetic circuit that I plan to make for the final project aims to detect different biological signals and produce a measurable output. The input will be one among the environmental signals, IL-6 or low O₂, and the output will be a green fluorescence signal or a therapeutic peptide. Could this function be realized by cell-free Tx/Tl alone, without encapsulation? The system that I am thinking of needs to be encapsulated inside a hydrogel. Could this function be realized by genetically modified natural cells? Cells do have a mechanism to respond to real signals in the body, but getting therapeutic peptides and other luminescent signals as an output from a signal is achieved if the cell is preprogrammed and the genetic circuit is assembled in a way to detect the signal and respond accordingly. Describe the desired outcome of your synthetic cell operation. Output will be a Green Fluorescence Signal. Design all components that would need to be part of your synthetic cell. What would the membrane be made of?</description><generator>Hugo</generator><language>en</language><atom:link href="https://pages.htgaa.org/2026a/kaleab-berhanu-weldesenbet/homework/week-09-hw-cell-free-systems/index.xml" rel="self" type="application/rss+xml"/></channel></rss>