https://pages.htgaa.org/2026a/keerthana-gunaretnam/homework/week-05-hw-protein-design-part-ii/index.htmlPart A: SOD1 Binder Peptide Design (From Pranam) Superoxide dismutase 1 (SOD1) is a cytosolic antioxidant enzyme that converts superoxide radicals into hydrogen peroxide and oxygen. In its native state, it forms a stable homodimer and binds copper and zinc. Mutations in SOD1 cause familial Amyotrophic Lateral Sclerosis (ALS). Among them, the A4V mutation (Alanine → Valine at residue 4) leads to one of the most aggressive forms of the disease. The mutation subtly destabilizes the N-terminus, perturbs folding energetics, and promotes toxic aggregation. Your challenge: Design short peptides that bind mutant SOD1. Then decide which ones are worth advancing toward therapy. You will use three models developed in our lab: PepMLM: target sequence-conditioned peptide generation via masked language modeling https://colab.research.google.com/drive/1z37YcBtwhd-RzNrWaTiKUhTHwZGKzdGc?usp=sharingHugoen