https://pages.htgaa.org/2026a/kevin-garwood/homework/week-05-hw-protein-design-part-ii/index.htmlPart 1: Generate Binders with PepMLM Begin by retrieving the human SOD1 sequence from UniProt (P00441) and introducing the A4V mutation. I visited the Uniprot page for (P00441)[https://www.uniprot.org/uniprotkb/P00441/entry#sequences] and the normal sequence is: 012345… MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ A4V represents one mutation where the ‘A’ changes to a ‘V’ at position 4: MATKVVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ I found additional information about the AV4 mutation on the ALS Association’s pageHugoen