<?xml version="1.0" encoding="utf-8" standalone="yes"?><rss version="2.0" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Week 5 HW: Protein Design Part 2 :: 2026a-mariana-kanbe</title><link>https://pages.htgaa.org/2026a/mariana-kanbe/homework/week-05-hw-protein_design_pt2/index.html</link><description>Part A: SOD1 Binder Peptide Design (From Pranam) Part 1: Generate Binders with PepMLM
Question 1
This is human SOD1 sequence from UniProt (P00441) removing the initial Met
ATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ FASTA
introducing the A4V mutant associated with the most aggressive forms of the ALS disease ATKVVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
Question 2 and 3
With the help of ChatGPT and Gemni, I generated 2 new cells ir order to generate four peptides of length 12 amino acids conditioned on the mutant SOD1 sequence.</description><generator>Hugo</generator><language>en</language><atom:link href="https://pages.htgaa.org/2026a/mariana-kanbe/homework/week-05-hw-protein_design_pt2/index.xml" rel="self" type="application/rss+xml"/></channel></rss>