https://pages.htgaa.org/2026a/robert-sheng/homework/week-05-hw/index.htmlPart A: SOD1 Binder Peptide Design 1. Background and Design Goal Superoxide dismutase 1 (SOD1) is a cytosolic antioxidant enzyme that converts superoxide radicals into hydrogen peroxide and oxygen. In its native state, SOD1 forms a stable homodimer and binds copper and zinc cofactors. Mutations in SOD1 are associated with familial ALS; among them, the A4V variant is one of the aggressive disease-associated variants and has been linked to SOD1 destabilization, altered folding behavior, and toxic aggregation.Hugoen