https://pages.htgaa.org/2026a/sami-tanveer/homework/week-05-hw-protein-design-part-ii/index.htmlPart A: SOD1 A4V Therapeutic Peptide Design 1. Project Overview & Pharmacological Target This research targets the A4V mutation (Alanine-to-Valine at residue 4) in human Superoxide Dismutase 1 (SOD1). In Pharmaceutical Sciences, this is a critical target for Familial ALS. The mutation destabilizes the N-terminal “zipper” of the protein, leading to the exposure of hydrophobic residues and subsequent toxic aggregation. Our goal is to design a peptide binder that cap-stabilizes this region.Hugoen