https://pages.htgaa.org/2026a/sayaka-shimada/homework/week-04-hw-protein-design-part-i/index.html‘Week 4 HW: Protein Design Part I’ Documentation Homework: Protein Design I — DUE BY START OF MAR 3 LECTURE Part A. Conceptual Questions Answer any NINE of the following questions from Shuguang Zhang: (i.e. you can select two to skip): 1. How many molecules of amino acids do you take with a piece of 500 grams of meat? (on average an amino acid is ~100 Daltons) 2. Why do humans eat beef but do not become a cow, eat fish but do not become fish? 3. Why are there only 20 natural amino acids? 4. Can you make other non-natural amino acids? Design some new amino acids. 5. Where did amino acids come from before enzymes that make them, and before life started? 6. If you make an α-helix using D-amino acids, what handedness (right or left) would you expect? 7. Can you discover additional helices in proteins? 8. Why are most molecular helices right-handed? 9. Why do β-sheets tend to aggregate? ・What is the driving force for β-sheet aggregation? 10. Why do many amyloid diseases form β-sheets? ・Can you use amyloid β-sheets as materials? 11. Design a β-sheet motif that forms a well-ordered structure. ☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆Hugoen