Homework
Weekly homework submissions:
Week 1 HW: Principles and Practices
Table of Contents 1) Biological engineering application / tool 2) Governance / policy goals 3) Governance actions 4) Scoring governance actions 5) Governance Prioritization and Recommendation 1) Biological engineering application tool I want to develop and why Engineered probiotics for therapeutic compound delivery
Homework Questions from Professor Jacobson Question 1. Nature’s machinery for copying DNA is called polymerase. What is the error rate of polymerase? How does this compare to the length of the human genome? How does biology deal with that discrepancy? DNA polymerase has an error rate on the order of 1 error per 106 bases. Compared to the size of the human genome, about 3 × 109 base pairs, this would imply thousands of errors per genome replication. Biology addresses this mismatch by adding layers of correction: polymerases can proofread during synthesis, and additional mismatch repair pathways correct many of the errors that still escape proofreading.