https://pages.htgaa.org/2026a/srinidhi-vasan/homework/week-05-protein-design-part-ii/index.htmlSOD Peptide Design from Pranam Superoxide dismutase 1 (SOD1) is a cytosolic antioxidant enzyme that converts superoxide radicals into hydrogen peroxide and oxygen. In its native state, it forms a stable homodimer and binds copper and zinc. Mutations in SOD1 cause familial Amyotrophic Lateral Sclerosis (ALS). Among them, the A4V mutation (Alanine → Valine at residue 4) leads to one of the most aggressive forms of the disease. The mutation subtly destabilizes the N-terminus, perturbs folding energetics, and promotes toxic aggregation. Your challenge: a. Design short peptides that bind mutant SOD1. b. Then decide which ones are worth advancing toward therapy.Hugoen