Targetting Mycobacterium tuberculosis DnaA Domain 4 for novel antitubercular drug discovery using an in silico approach This image was generated with the help of NotebookLM AI tool.
Abstract Tuberculosis is one of the leading causes of death in the world, which is caused by Mycobacterium tuberculosis. A lot of struggles exist in treating TB, mainly due to persisters and drug resistance in TB. Currently many strategies are being researched to improve the treatment effectiveness and efficiency. My project aims to target a particular domain from a new protein from M. tuberculosis and find potential inhibitors against it to contribute to TB treatments. My protein of choice is DnaA, the essential replication initiator in M.tuberculosis. This underexplored, biologically validated protein is particularly exciting, given that it is essential for replication of the genome and has no known human homologs, thus targeting a protein where developing resistance could be difficult and have minimal to no off target effects. The domain of choice is Domain 4 - the DNA binding domain, chosen for the same features: essential and highly conserved.
