<?xml version="1.0" encoding="utf-8" standalone="yes"?><rss version="2.0" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Week 5 HW: Protein Design II :: 2026a-yao-wang</title><link>https://pages.htgaa.org/2026a/yao-wang/homework/week-05-hw-proteindesign-ii/index.html</link><description>Part 1 1. Retrieve SOD1 sequence and introduce A4V MATKVCVVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
2. PepMLM-generated 12-aa peptides + known binder (lower = higher model confidence in the binder).
ID Peptide (12 aa) Source Perplexity (PepMLM) P1 WHSPVAAARLKE PepMLM 11.721713 P2 KRYGAAAARHKK PepMLM 11.211369 P3 WRYPVAGLALKE PepMLM 13.068802 P4 WHSPPAAVALGE PepMLM 12.159801 Ref FLYRWLPSRRGG known SOD1 binder N/A Observation (PepMLM confidence by perplexity):
Among generated candidates, P2 (KRYGAAAARHKK) has the lowest perplexity (highest PepMLM confidence), while P3 (WRYPVAGLALKE) has the highest perplexity (lowest confidence among the four).</description><generator>Hugo</generator><language>en</language><atom:link href="https://pages.htgaa.org/2026a/yao-wang/homework/week-05-hw-proteindesign-ii/index.xml" rel="self" type="application/rss+xml"/></channel></rss>