https://pages.htgaa.org/2026a/zarias-arman-aelius-saadatkhah/homework/week-05-hw-protein-design-part-ii/index.htmlPart A: SOD1 Binder Peptide Design Superoxide dismutase 1 (SOD1) is a cytosolic homodimeric antioxidant enzyme that converts superoxide radicals (O₂⁻) into hydrogen peroxide and molecular oxygen. It coordinates copper and zinc ions essential for catalysis and structural integrity. The A4V mutation — Alanine → Valine at residue 4 of the mature protein (residue 5 in the UniProt P00441 precursor) — causes one of the most aggressive familial ALS subtypes by subtly destabilizing the N-terminal β-strand and promoting toxic SOD1 misfolding and aggregation.Hugoen