HTGAA Governance Framework: Week 1
HTGAA 2026 / Week 1 / Governance

DIY Aging Biomarkers
for Community Labs

A proposal to lower the single biggest barrier to longevity research - cost - through an affordable, open-source testing kit.

ยพ of global deaths linked to aging
$500+ cost per commercial assay
~50 community biolabs worldwide

Policy Objectives

01.

Democratize Access

Lower financial and institutional barriers so independent researchers and scientists in low-resource settings can meaningfully contribute to aging research.

02.

Prevent Misuse

Ensure that wider access to bioengineering tools does not enable unsafe practices or malicious applications through proactive monitoring and education.

03.

Ensure Translation

Guarantee that research outcomes produced with accessible tools meet quality standards sufficient for peer review and eventual translation.

Proposed Interventions

Action 01 Incentive

Government Subsidies

Funding for non-traditional research environments is severely limited. A dedicated subsidy or micro-grant program (โ‚ฌ5โ€“25K) for community labs would accelerate biomedical progress by enabling new and existing scientists to carry out independent aging research.

Actor: Government funding bodies (NIH, ERC)

Risks & Trade-offs

Could create a two-tier system where funded labs professionalize and lose grassroots accessibility.

Action 02 Coordination

Lab Space Sharing Network

An "Airbnb for lab benches" connecting institutions with spare capacity to independent researchers. Researchers book time at subsidized rates; institutions benefit from utilization metrics and tax incentives.

Actor: Academic institutions, Incubators

Risks & Trade-offs

Institutions may refuse due to liability concerns; could expose institutions to safety incidents from external researchers.

Action 03 Technical

AI Biosafety Co-Pilot

A software tool that checks experiment plans against biosafety databases, flags risks, and requires mentor sign-off for high-risk procedures. Serves as a dynamic guardrail for junior researchers.

Actor: Open-source developers, DIYbio.org

Risks & Trade-offs

Over-reliance could reduce researchers' own safety judgment (the "GPS effect").

Impact Assessment

CriteriaSubsidiesLab NetworkAI Co-Pilot
Access DemocratizationMostMostIndirect
Enables new talent
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Enables existing researchers
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Misuse Preventionโ€”โ€”Most
Ensures safety standards
โ€”
โ€”
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Blocks malign apps
โ€”
โ€”
โœ“
TranslationPartialPartialโ€”
Incentivizes translation
โœ“
โœ“
โ€”
Directly aids translation
โœ“
โœ“
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FeasibilityLowMediumHigh
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Applies
โ€”
N/A
Strategy

Strategic Conclusion

01. Safety First

Build the safety layer first.

The AI Co-Pilot is the most feasible starting point. It builds the trust required for institutional partnerships.

02. Infrastructure

Unlock lab sharing second.

Institutions are more likely to share space if a credible safety system exists.

03. Funding

Secure funding long-term.

Large-scale government buy-in requires both demonstrated safety and functional infrastructure.

Ethical Reflections

Access vs. Safety

Lowering barriers inevitably increases risk. There is no clean resolution, only thoughtful calibration of guardrails.

The "GPS Effect"

Over-reliance on safety tools might atrophy researchers' own judgment. Tools must teach, not just gate.

Exclusion

Regions without internet or institutions remain left out. True democratization may require a physical, offline kit.

Human Samples

If DIY aging research eventually involves human-derived samples, the absence of IRB oversight creates ethical gaps around consent.

HTGAA 2026 ยท Week 1 Homework
References: Lรณpez-Otรญn et al. (2023) ยท Ocampo et al. (2016)