https://pages.htgaa.org/2026b/barry-ng/week-01-hw-project-ideas/index.htmlRevised Idea: Manufacturable APOBEC3A for epigenetic-age measurement What would I like to biomanufacture and why? I want to biomanufacture APOBEC3A (A3A), the cytidine deaminase that makes bisulfite-free DNA methylation sequencing possible, using E. coli — and to fix the specific reason it is hard to make, which is that the enzyme mutates its own expression plasmid while the bacteria are building it. Methylation patterns are the basis of epigenetic clocks, the main quantitative measure of biological age we currently have, so this is a contribution to aging research, to make a cheaper, more reliable version of the reagent the measurement depends on.Hugoen