<MAGDA HAMILTON> — HTBAA Fall 2026

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About me

Engineer and artist-researcher. I build simulations where abstract phenomena — memory, thought, interiority — are given physical substance through code and physics.

Contact info

Homework, Labs, and Projects

See the nav bar on the left to look through my work for How To Biomanufacture Almost Anything (Fall 2026)!

Subsections of <MAGDA HAMILTON> — HTBAA Fall 2026

Week 1 HW: Final Project Ideas

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What I Would Like to Biomanufacture

I propose to biomanufacture a living bioluminescent surface as an art artifact — a material that emits light in response to touch and retains a fading memory of contact patterns over time.

My motivation is artistic and conceptual. My practice centers on the relationship between material behavior and perception — specifically, on systems whose internal logic is real but not immediately recoverable from observation. I am interested in memory as a material property: the idea that a substance can hold a trace of what has touched it, not as data storage but as a physical shift in how it behaves. A bioluminescent surface that responds differently to repeated contact than to first contact — that is brighter, or slower to fade, where a hand has been before — enacts this principle in living matter.

The artifact would take the form of a dark enclosure containing a cultivated dinoflagellate suspension or biofilm. When touched or disturbed, the organisms emit blue-green bioluminescence. In sustained darkness or with long-exposure photography, the cumulative pattern of contact becomes visible — a map of attention, of repeated gesture, of where a hand has been. The material does not reset cleanly. It holds something of what has touched it.

What Living System I Would Use

I would use Pyrocystis fusiformis or Noctiluca scintillans, both well-documented bioluminescent dinoflagellates, as the biological chassis. These organisms produce light mechanically — the act of disturbing the cell membrane triggers a calcium-mediated action potential that activates luciferase, producing a flash of blue-green light (peak ~475 nm).

The system inputs: mechanical disturbance (touch, pressure wave, fluid movement). The biological process: mechanosensitive ion channels open → calcium influx → luciferase-luciferin reaction → photon emission. The output: localized bioluminescent flash, duration ~100–500ms per stimulus.

For the memory component, I would explore two approaches: (1) conditioning the culture to produce sustained afterglow through genetic or chemical modification of the recharge cycle, or (2) embedding organisms in a biofilm or hydrogel matrix where physical deformation from contact persists longer than in free suspension, creating a structural memory of touch that correlates with light emission patterns.

Assumption: sustained or patterned bioluminescence can be achieved through matrix embedding or strain selection. This would need experimental validation.

How I Would Use Automation

I would use a desktop liquid-handling robot (e.g., Opentrons OT-2) for culture maintenance, dilution, and transfer — automating the daily feeding, pH monitoring, and passaging required to keep dinoflagellate cultures healthy and consistently bioluminescent.

For the artistic application, I would use programmable microfluidics to control the flow of culture medium across a surface, enabling spatial patterning of organism density. This allows me to design the surface’s luminescent responsiveness — denser regions glow more brightly, creating an intentional material gradient.

At prototype scale, automation handles the biology so I can focus on the spatial and interactive design of the artifact.

How Much and How Long

Scale definition: A single art installation — one panel approximately 60cm × 60cm, 5mm deep, containing a dinoflagellate suspension or biofilm.

Volume estimate:

  • Panel volume: 60 × 60 × 0.5 cm = 1,800 cm³ ≈ 1.8L of culture
  • Typical dinoflagellate culture density: ~500–1,000 cells/mL
  • Required: ~1.8L at working density

Production timeline:

  • Pyrocystis fusiformis doubling time: ~3–5 days under 12:12 light/dark cycle
  • From 50mL stock to 1.8L: ~3–4 doublings → 12–20 days
  • With Opentrons: minimal manual intervention, ~3 weeks total
  • At larger scale (10 panels): parallel bioreactors, ~6–8 weeks

What I Don’t Know Yet:

  1. Sustained memory: Can bioluminescent afterglow be extended beyond ~500ms without genetic modification?
  2. Biofilm stability: Can dinoflagellates be embedded in a hydrogel while maintaining viability over weeks?
  3. Spatial control: How uniform is bioluminescent response at the density required for aesthetic legibility?

Final Project

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