HW1: De novo design of Foci Protein Antagonists with Deep Learning

HW1: De novo design of Foci Protein Antagonists with Deep Learning :: rishabh-anandhttps://pages.htgaa.org/2026b/rishabh-anand/week-01-hw-project-ideas/index.htmlRishabh Anand (rshb@mit.edu) • HTBAA Homework 1 • Sept 2026 What you would like to biomanufacture and why? DNA randomly undergoes damage, and special dedicated Foci proteins are involved in DNA repair in the nucleus. I’d like to use deep learning methods to de novo design antagonist binders to RAD51, one such enzyme involved in this process (among other such proteins). If we can disrupt the DNA repeat mechanism, we can potentially use such binders to stop cancer cells from fixing their DNA and replicating.Hugoen