https://pages.htgaa.org/2026b/wissal-abderrahmani/index.htmlAbout me Hi, I’m Wissal, a molecular biology engineer fascinated by synthetic biology, mammalian cell engineering, and anything related to using biology to solve real-world problems 💫 I love learning new things, meeting new people, and discovering new cultures. I enjoy discussions about philosophy, history, and psychology. I believe interdisciplinarity holds great potential for addressing some of the most challenging issues of our century, and I particularly value HTB(G)AA’s constructionist approach to learning and its vision of radical inclusion.Hugoenhttps://pages.htgaa.org/2026b/wissal-abderrahmani/week-01-hw-project-ideas/index.htmlMon, 01 Jan 0001 00:00:00 +0000https://pages.htgaa.org/2026b/wissal-abderrahmani/week-01-hw-project-ideas/index.htmlKiller T cells surrounding a cancer cell. Image source: Harvard Medical School A Programmable SynNotch CAR-T Platform for Neuroblastoma 1.🪄 What I would like to biomanufacture, and Why ? Neuroblastoma is a cancer of the developing nervous system that primarily affects children. Although treatment outcomes have improved, patients with high-risk, relapsed, or refractory disease continue to have limited effective therapeutic options.https://pages.htgaa.org/2026b/wissal-abderrahmani/week-02-hw-dna-design/index.htmlMon, 01 Jan 0001 00:00:00 +0000https://pages.htgaa.org/2026b/wissal-abderrahmani/week-02-hw-dna-design/index.htmlBuilding the GD2-SynNotch–GPC2 CAR-T Genetic Circuit This week, I translated the therapeutic concept proposed in Homework 1 into defined genetic parts and three buildable lentiviral constructs. GD2 sensing → SynNotch activation → GPC2-CAR + EGFP expression → GPC2 recognition → T-cell activation + mbIL-15 support 1. 🧬 Define the expression target 1.a What molecules am I expressing? For my project, I will express two synthetic receptors (GD2-SynNotch and GPC2-CAR), one membrane-tethered cytokine (IL-15), and a fluorescent reporter (EGFP).https://pages.htgaa.org/2026b/wissal-abderrahmani/final-project/index.htmlMon, 01 Jan 0001 00:00:00 +0000https://pages.htgaa.org/2026b/wissal-abderrahmani/final-project/index.html